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Has the oxidative stress a role in late phase of experimental acute necrotizing pancreatitis?
Mehmet Yasar1, M Refik Mas, Bilgin Comert
1Gülhane School of Medicine, Department of Surgery, Etlik, 06018, Ankara, Turkey.
Background/Aims:
Reactive oxygen species and derivatives which are implicated in pathogenesis of pancreatitis are a group of substances which may provide distribution of proenzymes following destruction of acinary cells and may activate lysosomal enzymes. We aimed to show that oxidative stress in rats rendered acute necrotizing pancreatitis experimentally.
Methodology:
Twenty Spraque-Dawley rats were included into the study and they were divided into the subgroups of pancreatitis and controls. Taurocholate (3%) in doses of 1 mL/kg was administered into the biliopancreatic duct of the rats to render them with acute necrotizing pancreatitis. Rats were killed at 48 hours after the procedure. Malondealdehyde levels and superoxide dismutase activities in pancreatic tissue and erythrocytes were determined.
Results:
Significantly elevated tissue and erythrocyte malondealdehyde levels were found in rats with pancreatitis (p < 0.001). Superoxide dismutase activities in both tissues and erythrocytes of the rats with pancreatitis were significantly lower than those of the controls (p < 0.001).
Conclusions:
High levels of malondealdehyde in tissues and erythrocytes reveal the importance of reactive oxygen species in this process. To reveal the reason of decreased activities of superoxide dismutase in tissues and erythrocytes of the rats with pancreatitis may lead to a better understanding of pathogenesis of the disease and appearance of new treatment modalities.
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Acute Pancreatitis II: Pathophysiology
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Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis I: Introduction

