Apomorphine-induced aggression: an evaluation of possible sensitizing factors in the rat

The effects of prior experience with fighting and prior experience with both apomorphine and fighting were evaluated as possible sensitizing factors in rat intraspecific aggression induced by apomorphine. Results revealed that prior experience with the drug alone, or with fighting alone, had no effect on apomorphine-induced aggression. However, animals that had previously fought under the influence of apomorphine showed even higher levels of aggression suggesting that repeated experience with both the drug and fighting induces a type of sensitization.