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Premenstrual exacerbations of mood disorders

M N Miller1, B E Miller

  • 1Department of Psychiatry, East Tennessee State University, Quillen College of Medicine, Box 70567, Johnson City, TN 37614, USA. millerm@etsu.edu

Psychopharmacology Bulletin
|October 26, 2002
PubMed

Premenstrual exacerbation of mood disorders has received little attention, despite the recent interest in premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). Differentiating between PMDD/PMS and other disorders, which worsen premenstrually, is a poorly understood diagnostic challenge. Controversy also focuses on a possible coexistence of PMDD and other mood disorders. This review discusses the differences between mood-disorder exacerbations and premenstrual disorders, evidence for premenstrual magnification of mood disorders, and possible mechanisms for these variations as well as clinical implications.

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