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Updated: Jun 3, 2026
10:12
Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Multifold and sequential cross-coupling reactions with indium organometallics
Miguel A Pena1, Ignacio Pérez, José Pérez Sestelo
1Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain.
Chemical Communications (Cambridge, England)
|October 26, 2002
Summary
This study demonstrates efficient palladium-catalyzed cross-coupling reactions using organoindium compounds and oligohaloarenes. The method achieves high yields with minimal reagent excess, low catalyst loading, and short reaction times.
Area of Science:
- Organic Chemistry
- Organometallic Chemistry
Background:
- Palladium-catalyzed cross-coupling reactions are vital in organic synthesis.
- Developing efficient methods using organometallic reagents is an ongoing challenge.
Purpose of the Study:
- To develop a novel palladium-catalyzed cross-coupling method.
- To utilize triorganoindium compounds with oligohaloarenes for efficient synthesis.
Main Methods:
- Sequential and multifold palladium-catalyzed cross-coupling reactions.
- Employing triorganoindium compounds and oligohaloarenes as substrates.
- Optimizing catalyst loading and reaction conditions.
Main Results:
- Successful execution of cross-coupling reactions with a small excess of organometallic reagent.
- Achieved high efficiency with low catalyst charge loading.
- Demonstrated short reaction times for the transformations.
Conclusions:
- The developed method offers an efficient and practical approach for synthesizing complex molecules.
- This strategy is valuable for accessing diverse organic structures through palladium catalysis.
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