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Gastrointestinal malignant lymphomas in Macedonia.
G Petrusevska1, A Stojanović, S Karagozov
1Institute of Pathology, Medical Faculty, Sv. Kiril and Metodij University, Skopje, Republic of Macedonia.
Summary
Malignant lymphomas frequently affect the gastrointestinal tract, predominantly as B cell types. This study analyzed 21 Macedonian cases, revealing common sites like the palate and stomach, and aiding diagnosis through immunohistochemistry.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Extranodal lymphomas commonly manifest in the gastrointestinal tract, including the oral cavity.
- Malignant lymphomas represent a significant group of neoplasms affecting various gastrointestinal sites.
Purpose of the Study:
- To investigate the histomorphological, immunohistochemical, and clinical characteristics of malignant lymphomas in a Macedonian cohort.
- To identify common gastrointestinal locations and subtypes of extranodal lymphomas.
Main Methods:
- Retrospective analysis of 21 diagnosed malignant lymphoma cases.
- Histomorphological and immunohistochemical evaluation, including CD20 and CD79a staining.
- Monoclonality assessment via light chain restriction.
Main Results:
- All 21 cases were B cell lymphomas, with diffuse large cell lymphoma being the most frequent subtype (47.6%).
- Common sites included the hard palate (33.3%), gastric (23.8%), and large intestinal wall (23.8%).
- Advanced stages (III/IV) were observed in 38.1% of cases, suggesting primary or secondary involvement of the GI tract.
Conclusions:
- The gastrointestinal tract is a common site for extranodal B cell lymphomas.
- Immunohistochemistry is crucial for differentiating lymphomas and distinguishing them from epithelial neoplasms.
- The presence of advanced stage lymphomas highlights the need for comprehensive diagnostic approaches in GI malignancies.