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Related Experiment Video

Updated: Jul 17, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Alzheimer's disease is a synaptic failure.

Dennis J Selkoe1

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA. selkoe@cnd.bwh.harvard.edu

Science (New York, N.Y.)
|October 26, 2002
PubMed
Summary

Early Alzheimer's disease impairs memory due to synaptic changes in the hippocampus. These synaptic dysfunctions are linked to amyloid beta protein

Area of Science:

  • Neuroscience
  • Neurology
  • Pathology

Background:

  • Alzheimer's disease (AD) initially presents as pure memory impairment.
  • Evidence points to hippocampal synaptic alterations preceding neuronal loss in early AD.

Purpose of the Study:

  • To investigate the early molecular mechanisms underlying memory deficits in Alzheimer's disease.
  • To explore the role of amyloid beta in synaptic dysfunction.

Main Methods:

  • Analysis of synaptic efficacy in hippocampal models.
  • Investigation of diffusible oligomeric assemblies of amyloid beta protein.

Main Results:

  • Subtle alterations in hippocampal synaptic efficacy characterize early AD.
  • Synaptic dysfunction is associated with amyloid beta oligomers.

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Visualizing the DNA Damage Response in Purkinje Cells Using Cerebellar Organotypic Cultures

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Related Experiment Videos

Last Updated: Jul 17, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Visualizing the DNA Damage Response in Purkinje Cells Using Cerebellar Organotypic Cultures
08:41

Visualizing the DNA Damage Response in Purkinje Cells Using Cerebellar Organotypic Cultures

Published on: December 27, 2024

Conclusions:

  • Amyloid beta oligomers are implicated in the synaptic dysfunction observed in early Alzheimer's disease.
  • Targeting amyloid beta may offer therapeutic strategies for early AD memory loss.