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[Spontaneous hyphema caused by Ginkgo biloba extract].

C Schneider¹, C Bord, P Misse

¹Service d'Ophtalmologie, CMC Gui de Chauliac, C.H.U. de Montpellier, France.

Journal Francais D'Ophtalmologie

|October 26, 2002

Summary

Ginkgo biloba extract was the sole cause of a patient's spontaneous hyphema. Stopping the supplement resolved the bleeding, suggesting Ginkgo biloba can induce hemorrhage without other risk factors.

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Area of Science:

Ophthalmology
Hematology
Pharmacology

Background:

Ginkgo biloba extract is widely used for its vascular protective effects, particularly in the elderly.
The extract is known to inhibit platelet aggregation.
Spontaneous hyphema is a rare but serious ocular condition.

Observation:

A patient presented with spontaneous hyphema originating from the iris margin.
The patient had been ingesting Ginkgo biloba extract for two weeks prior to symptom onset.
No other predisposing factors for hyphema were identified.

Findings:

Extensive ophthalmological and hematological investigations were performed, including platelet function tests and imaging.
Ginkgo biloba extract was identified as the unique cause of the hyphema.

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Cessation of Ginkgo biloba intake led to complete resolution of the hemorrhage.

Implications:

This case highlights a potential risk of hemorrhage associated with Ginkgo biloba use.
Clinicians should consider Ginkgo biloba as a potential cause of spontaneous hyphema, especially in patients without other risk factors.
Further research may be warranted to elucidate the precise mechanisms by which Ginkgo biloba can induce ocular bleeding.