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Published on: February 17, 2018
The prevalence of anemia in chronic heart failure
Hildegard Tanner1, Giorgio Moschovitis, Gabriela M Kuster
1Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.
Insights
Anemia is common in congestive heart failure patients, affecting 15% of those studied. Anemia prevalence increased with heart failure severity, correlating with NYHA functional class.
Area of Science:
- Cardiology
- Hematology
- Internal Medicine
Background:
- Anemia is frequently observed in patients with congestive heart failure (CHF).
- Anemia in CHF correlates with disease severity and can be treated to improve cardiac function.
Purpose of the Study:
- To determine the prevalence of anemia in patients with congestive heart failure.
- To investigate the relationship between anemia and the New York Heart Association (NYHA) functional class in CHF patients.
Main Methods:
- Retrospective analysis of 193 CHF outpatients (mean age 54).
- Patients were classified by NYHA functional class (I-IV).
- Exclusion criteria included secondary anemia or hemodialysis; etiology of heart failure was assessed.
Main Results:
- Anemia (hemoglobin <120 g/l) was present in 15% of patients.
- Anemia was significantly more prevalent in NYHA class III and IV (19%) compared to class I and II (8%).
- Left ventricular ejection fraction decreased with increasing NYHA class.
Conclusions:
- The prevalence of anemia in this CHF cohort was 15%.
- Anemia in CHF patients is correlated with NYHA functional class, indicating a link to disease severity.
Objectives:
To assess prevalence of anemia and its correlation with NYHA-class in patients with congestive heart failure.
Background:
Recently, it was reported that anemia in congestive heart failure patients is common and correlated with the severity of disease. In these patients with anemia, treatment with erythropoietin and intravenous iron improved cardiac function significantly.
Methods:
193 patients from a tertiary heart failure outpatient clinic (mean age 54 years) were included in a retrospective analysis. Fourteen patients were in NYHA-class I, 69 class II, 79 class III, and 31 class IV. All patients had clinical and laboratory evaluation, echocardiography and coronary angiography. Patients with secondary anemia or on hemodialysis were excluded. Etiology of heart failure was ischemic in 41%.
Results:
Anemia (hemoglobin<120 g/l) was present in 28 of 193 patients (15%). There was an inverse relationship between NYHA-class and left ventricular ejection fraction (NYHA-class I 45%, class II 32%, class III 25%, class IV 25%). Serum creatinine increased with NYHA-class. Hemoglobin levels were similar in all four NYHA-classes but there were significantly more patients with anemia in NYHA-class III and IV (19%) compared with class I and II (8%, P<0.05). Hemoglobin was similar in surviving patients (mean 140 g/l) and those who died or were transplanted (mean 136 g/l, ns).
Conclusions:
The prevalence of anemia in our heart failure service is 15% (compared with 56% in the literature) and is correlated to NYHA-class.
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