Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computer modelling of radiation-induced bystander effect.

Igor K Khvostunov1, Hooshang Nikjoo

  • 1Medical Radiological Research Centre, Obninsk, Russia.

Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
|October 29, 2002
PubMed
Summary

Radiation-induced genomic instability and bystander effects are established. A new diffusion model quantifies these effects, predicting cell survival and transformation from low molecular weight protein signals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monitoring Cytogenetic Effects in Peripheral Blood Lymphocytes of Thyroid Cancer Patients Receiving Radioiodine Treatment.

International journal of molecular sciences·2026
Same author

Modelling Cellular Response to Ionizing Radiation: Mechanistic, Semi-Mechanistic, and Phenomenological Approaches - A Historical Perspective.

Radiation research·2024
Same author

Modelling DNA damage-repair and beyond.

Progress in biophysics and molecular biology·2024
Same author

Cytogenetic Damage Induced by Radioiodine Therapy: A Follow-Up Case Study.

International journal of molecular sciences·2023
Same author

Verification of KURBUC-based ion track structure mode for proton and carbon ions in the PHITS code.

Physics in medicine and biology·2021
Same author

Monte Carlo Electron Track Structure Calculations in Liquid Water Using a New Model Dielectric Response Function.

Radiation research·2017

Area of Science:

  • Radiobiology
  • Cellular and Molecular Biology
  • Radiation Oncology

Background:

  • Genomic instability and bystander effects are known consequences of ionizing radiation exposure.
  • Cells not directly irradiated can still display radiation-induced effects, indicating intercellular communication.

Purpose of the Study:

  • To develop a quantitative model for the radiation-induced bystander effect.
  • To investigate the role of a diffusing low molecular weight protein as a bystander signal.

Main Methods:

  • A diffusion model was employed to simulate the spread of a bystander signal (low molecular weight protein) from irradiated cells.
  • Model calculations were validated against experimental data on cell survival in irradiated conditioned media.

Related Experiment Videos

Main Results:

  • The diffusion model successfully predicted experimental results for cell survival in conditioned media.
  • The model accurately describes the dose-effect relationship for cell survival and oncogenic transformation.

Conclusions:

  • The proposed diffusion model provides a quantitative framework for understanding radiation-induced bystander effects.
  • The model supports the hypothesis that a diffusible low molecular weight protein mediates these intercellular signaling phenomena.