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Related Experiment Videos

Choroid plexus tumours.

J E A Wolff1, M Sajedi, R Brant

  • 1Department of Pediatric Oncology, Alberta Children's Hospital, 1820 Richmond Road SW, Calgary, Alberta, Canada T2T 5C7. johannes.wolff@barmherzige-regensburg.de

British Journal of Cancer
|October 29, 2002
PubMed
Summary

Histology is key for choroid plexus tumours. Choroid plexus-papilloma has better survival than choroid plexus-carcinoma, with surgery recommended for both. Adjuvant therapy is advised for carcinoma, while papilloma may be monitored.

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Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Pathology

Background:

  • Choroid plexus tumours are rare epithelial brain neoplasms.
  • Limited data exists on their biology and optimal treatment strategies.

Purpose of the Study:

  • To identify prognostic factors for choroid plexus tumours.
  • To evaluate the impact of different treatment modalities on patient outcomes.

Main Methods:

  • A meta-analysis of 566 well-documented choroid plexus tumours from 1966-1998.
  • Database analysis to determine prognostic factors and treatment influences.

Main Results:

  • Histology significantly impacts survival: choroid plexus-papilloma shows higher survival rates than choroid plexus-carcinoma.

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  • Surgical resection is a relevant prognostic factor for both tumour types.
  • Radiotherapy improves survival in choroid plexus-carcinomas; chemotherapy showed limited response.
  • Tumour relapse is a poor prognostic factor for carcinoma but not papilloma.

    • Conclusions:

    • Radical surgical resection is the primary treatment for choroid plexus tumours.
    • Adjuvant therapy is recommended for choroid plexus-carcinoma.
    • A "wait and see" approach may be suitable for choroid plexus-papilloma post-surgery.