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[Origin of cortical interneurons: basic concepts and clinical implications].

¹Division of Neurobiología del Desarrollo, Instituto de Neurociencias, CSIC, Universidad Miguel Hernández, San Juan de Alicate, Alicate, España. o.marin@umh.es

Revista De Neurologia

|October 29, 2002

Summary

Cortical GABAergic interneurons, crucial for brain function, originate from the subpallium, not just the pallium. These neurons migrate tangentially to reach the cerebral cortex during development.

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Area of Science:

Neuroscience
Developmental Biology
Cellular Biology

Context:

GABAergic interneurons are vital for cerebral cortex function, regulating pyramidal neuron synchronization and development.
Traditionally, cortical neurons were thought to originate solely from the dorsal telencephalon (pallium).

Purpose:

This review summarizes factors controlling cortical interneuron specification.
It also details the mechanisms guiding their migration to the cortex.

Summary:

Recent research reveals that many cortical GABAergic neurons originate from subpallial progenitors.
These neurons undertake a significant tangential migration to reach their cortical destinations.

Impact:

Understanding interneuron origins and migration is key to comprehending cortical development and function.

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This knowledge can inform research into neurological disorders linked to interneuron dysfunction.