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Linear growth of prepubertal asthmatic Thai children receiving long-term inhaled corticosteroids

Nualanong Visitsunthorn1, Pranee Moungnoi, Aree Saengsiriwut

  • 1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|October 31, 2002
PubMed

Insights

Long-term inhaled corticosteroids at 300 microg/day for children with persistent asthma showed no significant impact on growth rates. Asthma severity and age at treatment initiation were key factors influencing growth in these children.

Area of Science:

  • Pediatric Pulmonology
  • Endocrinology
  • Clinical Trials

Background:

  • Persistent asthma in children often necessitates long-term inhaled corticosteroid (ICS) treatment.
  • Understanding the impact of ICS on growth is crucial for managing pediatric asthma.
  • This study investigates growth rates in Thai children with persistent asthma receiving ICS therapy.

Purpose of the Study:

  • To evaluate the effect of long-term inhaled corticosteroids on the growth rate of prepubertal asthmatic Thai children.
  • To identify factors influencing growth rate in this pediatric population.

Main Methods:

  • A controlled clinical trial involving 145 prepubertal asthmatic Thai children.
  • Study group (81 children) received long-term inhaled corticosteroids; control group (64 children) did not.
  • Growth rates, Insulin-like Growth Factor 1 (IGF 1), and Insulin-like Growth Factor Binding Protein 3 (IGFBP 3) were assessed.

Main Results:

  • Inhaled corticosteroids (300 microg/day for 9-60 months) did not significantly affect growth rates.
  • Linear regression indicated asthma severity and age at nasal corticosteroid initiation influence growth.
  • IGF 1 and IGFBP 3 levels were normal; height standard deviation scores were below average.

Conclusions:

  • Average doses of inhaled corticosteroids (300 microg/day for 9 months) do not significantly impact the growth rate of prepubertal asthmatic Thai children.
  • Asthma severity and age at treatment initiation are significant determinants of growth in these children.
Abstract

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