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Cyclic vomiting syndrome in Thai children.
Prapun Aanpreung1, Chirasri Vajaradul
1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Summary
Cyclic vomiting syndrome (CVS) in Thai children shows similar clinical features to other populations. Amitriptyline and pizotifen demonstrated effectiveness in managing vomiting episodes, with no reported side effects.
Area of Science:
- Pediatrics
- Gastroenterology
- Neurology
Background:
- Cyclic vomiting syndrome (CVS) is a severe childhood disorder with unknown causes.
- Limited data exists on CVS in Asian children.
- Understanding clinical manifestations and treatment responses in Thai children is crucial.
Purpose of the Study:
- To investigate the clinical characteristics of CVS in Thai children.
- To evaluate the efficacy of antimigraine prophylactic drugs for CVS.
- To assess treatment outcomes in this pediatric population.
Main Methods:
- Retrospective review of medical records of children diagnosed with CVS.
- Analysis of demographic data, clinical manifestations, treatments, and outcomes.
- Evaluation of drugs including pizotifen, amitriptyline, and propranolol.
Main Results:
- Twenty-five Thai children (13 female, 12 male) diagnosed with CVS were studied.
- Amitriptyline showed a good or fair response in 15 out of 18 patients (83.3%).
- Pizotifen had a good or fair response in 4 out of 8 patients (50%), with no statistically significant difference compared to amitriptyline.
Conclusions:
- Clinical features of CVS in Thai children resemble those reported globally, with fewer associated migraine headaches.
- Amitriptyline and pizotifen are effective prophylactic treatments for cyclic vomiting syndrome in children.
- Further research may be needed to explore optimal treatment strategies and underlying mechanisms.