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Updated: Aug 18, 2026

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Published on: May 22, 2014
Structure of interleukin-10/interleukin-10R1 complex: a paradigm for class 2 cytokine activation
1Department of Microbiology, University of Alabama at Birmingham, 35294, USA. walter@uab.edu
Abstract:
The class II alpha-helical cytokine family consists of eleven members including the interferons, interleukin-10 (IL-10) and several newly discovered IL-10 homologs. The molecules display a vast array of biologic activities including the ability to induce an antiviral state, modulate inflammatory responses, and inhibit cell growth. Biologic activity is dependent on cytokine-dependent aggregation of two different cell-surface receptors. The detailed protein-protein interactions that initiate these biologic responses are amenable to study using X-ray crystallographic methods. In this article, I summarize my laboratory's contributions to understanding these recognition processes using IL-10 as the prototypic class II cytokine.
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