Related Experiment Video
Updated: May 12, 2026

A Method of Nodose Ganglia Injection in Sprague-Dawley Rat
Published on: November 25, 2014
First model of spontaneous vagal hyperreactivity and its mode of genetic transmission
Angelo Livolsi1, Josiane Feldman, Josué Feingold
1Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France. Angelo.Livolsi@chru-strasbourg.fr
Background:
The main purpose of our study was to define an animal model of vagal hyperreactivity and its genetic transmission.
Methods And Results:
We first investigated the vagal reactivity with phenylephrine in conscious rabbits. Barosensitivity and the maximal bradycardic response were measured at the upper mean blood pressure plateau. Hyperreactive (H) animals were selected and crossbred with normal (N) ones. Results showed no significant difference between calculated barosensitivity values after the different doses of phenylephrine. In contrast, an increase of the values and a great dispersion appeared 1 to 5 beats after the end of the ramp. Marked pauses (6000 to 20 000 ms) were obtained with some rabbits, which were blocked by atropine. A significant excess of hyperreactive offspring was observed in HxH crossings compared with NxN ones (39.4% male and 42.3% female offspring versus 14.4% and 4.4%, respectively). Few female offspring were hyperreactive compared with males in NxH and NxN crossings (4.1% versus 23.4% and 4.4% versus 14.4%, respectively).
Conclusions:
This study describes the first model of spontaneous vagal pauses. The inheritance could be polygenic with a partial sex-limited character.
More Related Videos
08:16Detection of G Protein-coupled Receptor Expression in Mouse Vagal Afferent Neurons using Multiplex In Situ Hybridization
Published on: September 20, 2021
09:36Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
Related Concept Videos
Mutation, Gene Flow, and Genetic Drift
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Mechanism of Cardiac Arrhythmias
Pathophysiology of Vomiting
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...