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ErbB2 oncogene expression supports the acute pancreatitis-chronic pancreatitis sequence
Jens Standop1, Silke Standop, Atsushi Itami
1Eppley Institute, University of Nebraska Medical Center, Omaha, 68198-6805, USA.
Virchows Archiv : an International Journal of Pathology
|October 31, 2002
Summary
Chronic pancreatitis may develop from acute pancreatitis, as suggested by similar ErbB2 antibody expression patterns in recurrent acute and chronic pancreatitis tissues. This finding supports the necrosis-fibrosis sequence hypothesis for pancreatitis progression.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- The origins of chronic pancreatitis are debated, with theories including de novo development or progression from acute pancreatitis.
- Previous research indicated ErbB2 (a growth factor receptor) antibodies could differentiate pancreatitis types.
Purpose of the Study:
- To investigate ErbB2 expression patterns across acute, recurrent acute, and chronic pancreatitis.
- To explore the potential evolution of ErbB2 expression during pancreatitis progression.
Main Methods:
- Immunohistochemical analysis of pancreatic tissue specimens from normal, acute, and chronic pancreatitis groups.
- Utilized two polyclonal anti-ErbB2 antibodies (Santa Cruz and Dako) for staining.
Main Results:
- Santa Cruz antibody showed decreased islet cell immunoreactivity in acute pancreatitis, becoming negative in recurrent acute and chronic pancreatitis.
- Dako antibody revealed membrane staining in ductal cells of chronic and some recurrent acute pancreatitis specimens.
Conclusions:
- Similar ErbB2 antibody immunoreactivity in recurrent acute and chronic pancreatitis supports the necrosis-fibrosis sequence hypothesis.
- Acute pancreatitis may serve as a precursor to chronic pancreatitis.