Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.3K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.3K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

993
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
993
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

938
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
938
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

849
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
849
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

797
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
797
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

972
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
972

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exosome-mediated transfer of NOD2 from platelets to monocytes: a novel therapeutic target for atherosclerosis.

Biochemical pharmacology·2026
Same author

Platelet RIP2 Limits Dense Granule Release and Thrombosis via DOCK8-Cdc42.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Social determinants of health and sex differences: insights from NIH Specialized Centers of Research Excellence (SCORE).

Biology of sex differences·2026
Same author

IBS stress reactivity phenotype is associated with blood transcriptome profiles and microstructural and functional brain changes.

Neurobiology of stress·2026
Same author

Correction to: Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis.

The American journal of gastroenterology·2026
Same author

Recommendations for the Evaluation and Management of Inflammatory Bowel Disease With Irritable Bowel Syndrome-Like Symptoms: A Joint Rome Foundation and International Organization for the Study of IBD (IOIBD) Consensus.

Gastroenterology·2026
Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026
Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026
Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026
Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026
Same journal

Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.

Gastroenterology·2026
Same journal

Reply.

Gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Feb 27, 2026

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
06:04

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: January 17, 2025

1.7K

Gender differences in irritable bowel syndrome.

Lin Chang1, Margaret M Heitkemper

  • 1UCLA/CURE Neuroenteric Disease Program, Department of Medicine, and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA. linchang@ucla.edu

Gastroenterology
|October 31, 2002
PubMed
Summary
This summary is machine-generated.

Women experience functional pain disorders like irritable bowel syndrome more often than men. Research explores physiological and psychological factors contributing to these gender differences in prevalence and treatment response.

More Related Videos

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
03:25

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment

Published on: December 27, 2024

1.7K
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.7K

Related Experiment Videos

Last Updated: Feb 27, 2026

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling
06:04

Functional Near-Infrared Spectroscopy Hyperscanning Study in Psychological Counseling

Published on: January 17, 2025

1.7K
Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment
03:25

Author Spotlight: Exploring Non-Pharmacological Therapies for Chronic Respiratory Diseases — Linking Intestinal Microbiome Insights to COPD Treatment

Published on: December 27, 2024

1.7K
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.7K

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Psychology

Background:

  • Functional pain disorders, such as irritable bowel syndrome (IBS), are more prevalent in women across Western cultures.
  • Gender disparities are also noted in drug therapy responsiveness for these conditions.
  • Understanding these gender differences is crucial for effective treatment.

Purpose of the Study:

  • To explore the physiological and psychological factors contributing to gender-related differences in functional pain disorders.
  • To investigate the potential impact of neuroendocrine, autonomic nervous system, and stress reactivity on gut function and pain perception in women versus men.
  • To examine the role of psychological characteristics and history of abuse in the higher prevalence of IBS in women.

Main Methods:

  • Review of existing clinical trials and research studies examining gender differences in IBS.
  • Analysis of physiological measures including gastrointestinal transit time, visceral sensitivity, and central nervous system pain processing.
  • Evaluation of the influence of sex hormones (estrogen, progesterone), neuroendocrine factors, and autonomic nervous system activity.
  • Assessment of psychological factors such as somatization, depression, anxiety, and history of sexual abuse.

Main Results:

  • Physiological gender differences exist in gut function, visceral sensitivity, and pain processing.
  • Hormonal, neuroendocrine, and autonomic nervous system factors may contribute to gender-specific gut responses.
  • Psychological elements like depression, anxiety, and past trauma are associated with higher IBS prevalence in women.
  • Observed gender differences in response to serotonergic agents warrant further investigation into non-drug therapy responses.

Conclusions:

  • Gender influences the prevalence and potentially the treatment of functional pain disorders like IBS.
  • A multifactorial approach considering physiological, hormonal, and psychological elements is necessary to understand these gender disparities.
  • Further research is needed to clarify the mechanisms underlying gender differences in gut motility, sensitivity, and response to various therapies, including non-drug interventions.