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A double-blind, placebo-controlled trial of sertraline in depressed adolescent alcoholics: a pilot study
Deborah Deas1, Carrie L. Randall, James S. Roberts
1Medical University of South Carolina, Center for Drug and Alcohol Programs, 67 President Street, PO Box 250861, Charleston, SC 29425, USA.
Abstract:
In order to preliminarily evaluate the efficacy, safety and tolerability of the serotonin reuptake inhibitor, sertraline, in the treatment of adolescents with a primary depressive disorder and a comorbid alcohol use disorder, a 12-week double-blind, placebo-controlled trial of sertraline plus cognitive behavior group therapy was conducted. Subjects were 10 outpatient treatment-seeking adolescents. Baseline assessment included the K-SADS, HAM-D, SCID, and the Time-Line Follow-Back. The HAM-D and the Time-Line Follow-Back were performed weekly thereafter. Both groups showed a significant reduction in depression scores with an average reduction between baseline and endpoint HAM-D score of -9.8 (F(1,8)=26.14, p