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[Chromophobe cell renal carcinoma. Clinico-pathologic study of 36 cases]
Isabel Alvarado-Cabrero1, Adriana Atencio-Chan, Claudia Rodríguez
1Servicio de Anatomía Patológica, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc No. 330, col. Doctores, Delegación Cuauhtémoc, C.P. 06725, Distrito Federal, México. isa98@prodigy.net.mx
Introduction:
Chromophobe renal cell carcinoma (CCRC) comprises 5% of neoplasms of renal tubular epithelium. CCRC may have a slightly better prognosis than clear cell carcinoma, but outcome data are limited.
Objective:
In this study, we analyzed 250 renal cell carcinomas to a) determine frequency of CCRC at our Hospital and b) analyze clinical and pathologic features of CCRCs.
Methods:
A total of 250 renal carcinomas were analyzed between March 1990 and March 1999. Tumors were classified according to well-established histologic criteria to determine stage of disease; the system proposed by Robson was used.
Results:
Of 250 renal cell carcinomas analyzed, 36 were classified as chromophobe renal cell carcinoma, representing 14% of the group studied. The tumors had an average diameter of 14 cm. Robson staging was possible in all cases, and 10 patients were stage 1) 11 stage II; 10 stage III, and five stage IV. The average follow-up period was 4 years and 18 (53%) patients were alive without disease.
Conclusion:
The highly favorable pathologic stage (RI-RII, 58%) and the fact that the majority of patients were alive and disease-free suggested a more favorable prognosis for this type of renal cell carcinoma.