Related Experiment Videos
[Neuroleptic-induced movement disorders: historical perspectives]
M A Wolf1, R Yassa, P M Llorca
1Centre Hospitalier Douglas, Centre de Psychiatrie Communautaire, 6875, boulevard LaSalle, Verdun, Québec, Canada, H4H 1R3.
L'Encephale
|November 1, 1993
Summary
Neuroleptic-induced parkinsonism and tardive dyskinesia are neurological side effects of antipsychotic medications. Research has evolved, identifying risk factors like age and gender, but these conditions remain a therapeutic challenge.
Area of Science:
- Neurology
- Psychopharmacology
Context:
- The discovery of neuroleptics in the mid-20th century led to the identification of neurological side effects, specifically extrapyramidal symptoms.
- Early descriptions of neuroleptic-induced parkinsonism date back to the 1950s, with ongoing debate about its nature as a side effect or therapeutic action.
Purpose:
- To trace the historical emergence and characterization of neuroleptic-induced parkinsonism and tardive dyskinesia.
- To review the evolution of terminology and understanding of these neurological side effects.
- To summarize early epidemiological findings and evolving risk factors for tardive dyskinesia.
Summary:
- Neuroleptic-induced parkinsonism was first described in the 1950s, coinciding with the introduction of neuroleptic drugs.
- Tardive dyskinesia, characterized by persistent involuntary movements, was reported in the late 1950s and formally termed in 1964.
- Early epidemiological studies revealed wide prevalence rates, with later research highlighting older age and female gender as key risk factors.
Impact:
- Understanding the historical context of these side effects is crucial for current clinical practice and research.
- The persistent challenge of managing tardive dyskinesia underscores the need for safer antipsychotic alternatives.
- Variations in clinical presentation and interest across regions may reflect differences in prescribing practices and medicolegal environments.