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[Intrathyroid metastases from kidney cancers: two case reports]
A Atmani1, D Valleix, S Blaise
1Service de chirurgie viscérale et transplantations, centre hospitalier universitaire Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. abdelhakimatmani@hotmail.com
Abstract:
The thyroid metastasis are under estimated in clinical practice because they are in the vast majority of cases "silent". Over than 50% of clinically apparent metastatic lesions are due to kidney carcinomas. We report two cases of thyroid metastasis from clear-cell renal carcinoma occurred 3 years and 8 years after nephrectomies. The previous history of any type of carcinoma should suggest a possibility of metastasis for every thyroid nodules. Fine-needle aspiration cytology is recommended by some authors. Finally, clear-cell carcinoma metastases seem to have a propensity to occur in abnormal thyroid tissue and further study could be interesting.
Insights
Thyroid metastases from kidney cancer are often silent and underestimated. Early detection is crucial, as clear-cell renal carcinoma can metastasize to the thyroid years after kidney removal.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Thyroid metastases are frequently overlooked in clinical settings due to their asymptomatic nature.
- Kidney carcinomas are a significant source of clinically apparent metastatic lesions to the thyroid, accounting for over 50%.
Observation:
- This report details two cases of thyroid metastasis originating from clear-cell renal carcinoma.
- Metastases occurred 3 and 8 years post-nephrectomy in the presented cases.
- A history of prior carcinoma should raise suspicion for metastatic disease in any thyroid nodule.
Findings:
- Fine-needle aspiration cytology is a suggested diagnostic method for suspicious thyroid nodules.
- Clear-cell carcinoma metastases exhibit a tendency to manifest in pre-existing abnormal thyroid tissue.
Implications:
- Increased clinical awareness is needed for thyroid nodules in patients with a history of renal carcinoma.
- Further research into the predilection of clear-cell carcinoma metastases for abnormal thyroid tissue is warranted.
- This highlights the importance of considering secondary malignancy in thyroid nodule evaluation.