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[Serious invasive pneumococcal disease in young children: the importance of vaccination]

L M Haveman1, S P M Geelen, E A M Sanders

  • 1Afd. Kindergeneeskunde, Wilhelmina Kinderziekenhuis/Universitair Medisch Centrum Utrecht, Lundlaan 6, 3508 AB Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|October 31, 2002
PubMed

Insights

Invasive pneumococcal disease affects young children, with a 7-valent conjugate vaccine showing effectiveness in infants. This vaccine is recommended for infants and high-risk children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Invasive pneumococcal disease (IPD) is a significant cause of morbidity and mortality in young children.
  • The 23-valent pneumococcal polysaccharide vaccine is not effective in children under two years of age, the primary demographic affected by IPD.

Observation:

  • Three cases of IPD in infants are presented: pneumococcal sepsis with hemolytic uremic syndrome, fatal pneumococcal sepsis/meningitis, and pneumococcal cellulitis.
  • Two of the three affected children were under one year of age, highlighting the vulnerability of this age group.

Findings:

  • The 7-valent pneumococcal conjugate vaccine (PCV7) has been registered and demonstrated effectiveness in protecting infants and children against IPD.
  • The Health Council of the Netherlands recommended the inclusion of PCV7 in the routine infant vaccination schedule.

Implications:

  • Widespread infant vaccination with PCV7 can significantly reduce the burden of IPD in young children.
  • In the absence of universal vaccination, PCV7 is recommended for infants and children at high risk for invasive pneumococcal disease.

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