Related Experiment Video
Updated: Sep 28, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Abuse during pregnancy and stress because of abuse during pregnancy and birthweight
1Johns Hopkins University, School of Hygiene and Public Health, Baltimore, USA.
Objective:
to determine whether there is an independent association between physical abuse during pregnancy or stress because of emotional, sexual, or physical abuse during pregnancy and birthweight after adjusting for behavioral, psychosocial, demographic, and medical variables.
Methods:
We conducted a cross sectional study of 808 low-income women, age 18 years or older, who delivered single infants from pregnancies of 20 weeks or longer. Abuse during the current pregnancy was measured as reported events of physical abuse and stress because of emotional, sexual, or physical abuse. Multiple regression models were developed to estimate the association of low birthweight (LBW) and mean birthweight with abuse during pregnancy, adjusting for behavioral, psychosocial, demographic, and medical variables.
Results:
Physical abuse during pregnancy was not associated with LBW or with mean birthweight. Women who reported stress because of abuse had 2.1 times higher odds of LBW (95% CI 1.2, 3.6) than those who did not, and the mean birthweight of their infants was 236 g lower (95% CI -371, -102) than those of women who reported no stress because of abuse in the adjusted regression models. Furthermore, the adjusted mean birthweight for LBW infants of women reporting stress because of abuse was significantly lower (-372, 95% CI 595, -149) than for LBW infants of women reporting no stress.
Conclusions:
Stress because of abuse during pregnancy was associated with both LBW and lower mean birthweight after adjusting for behavioral, psychosocial, demographic, and medical variables.
Related Concept Videos
Stress Prevention and Stress Management Techniques IV
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Teratogenicity
Bulimia Nervosa
Introduction to Stress and Lifestyle
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...

