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Virilising adrenocortical carcinoma.

Dilip Kumar Pal1, Anup Kumar Kundu, Subrata Chakrabortty

  • 1Department of Surgery, North Bengal Medical College, Sushrutanagar, Darjeeling.

Journal of the Indian Medical Association
|October 31, 2002
PubMed
Summary

A rare virilizing adrenocortical carcinoma in a 16-year-old female caused a rapidly growing abdominal tumor, high blood pressure, and signs of excess androgens. Surgical removal was successful.

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Area of Science:

  • Endocrinology
  • Oncology
  • Pediatric Surgery

Background:

  • Adrenocortical carcinoma is a rare malignancy in children and adolescents.
  • Virilizing tumors of the adrenal gland can present with signs of hyperandrogenism.

Observation:

  • A 16-year-old female presented with a rapidly growing abdominal mass, primary amenorrhea, hirsutism, and severe hypertension.
  • Elevated serum testosterone levels and a left adrenal mass were identified on imaging.
  • Histopathology revealed a large adrenal tumor composed of cells with hyperchromatic nuclei and eosinophilic cytoplasm, along with giant cells.

Findings:

  • The patient was diagnosed with a virilizing adrenocortical carcinoma.
  • Surgical resection of the adrenal tumor was performed.
  • The tumor exhibited classic histopathological features of adrenocortical carcinoma.

Implications:

  • This case highlights the importance of considering adrenocortical tumors in the differential diagnosis of virilization and abdominal masses in adolescents.
  • Early diagnosis and surgical management are crucial for favorable outcomes in pediatric adrenocortical carcinoma.
  • Understanding the clinical and pathological features of virilizing adrenocortical carcinoma aids in timely intervention and patient care.

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