Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Host/pathogen interactions at mucosal surfaces: immune consequences.

Simon Clare1, Alan Huett, Gordon Dougan

  • 1Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London, UK.

Research in Microbiology
|October 31, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.

Nature communications·2026
Same author

Whole-genome sequencing to investigate the prevalence and transmission of multidrug-resistant Gram-negative pathogens in an adult intensive care unit in the UK.

Microbial genomics·2026
Same author

A disease model resource reveals core principles of tissue-specific cancer evolution.

Nature·2026
Same author

Vaccines and antimicrobial resistance: from science to policy-summary and outcomes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

A Novel Human Cellular System for Studying Normal Aging and for Anti-Aging Discovery.

Aging cell·2026
Same author

Tumor suppressor protein p53 governs human trophoblast lineage development.

Cell reports·2025
Same journal

Deletion of major shell proteins of ethanolamine utilization microcompartment reduces intrinsic antibiotic resistance, biofilm, and intracellular survival of Salmonella Typhimurium.

Research in microbiology·2025
Same journal

Dynamic exometabolomics reveals metabolic adaptations of Staphylococcus epidermidis to pH-mimicking skin and bloodstream.

Research in microbiology·2025
Same journal

Co-expression network insights into Leptospira interrogans pathogenesis.

Research in microbiology·2025
Same journal

Differential DNA methylation associated with virulence attenuation in Edwardsiella piscicida.

Research in microbiology·2025
Same journal

Klebsiella pneumoniae-induced pneumonia: Pathogenesis, immune interactions, and antimicrobial resistance in a global context.

Research in microbiology·2025
Same journal

Investigating inhibitory effect of sterol targeting compounds against B. anthracis: Membrane microdomain a probable target.

Research in microbiology·2025
See all related articles

The mucosal immune system protects the body from infection while preventing harmful responses to harmless antigens. Pathogenic bacteria and their toxins are key tools for studying these complex mucosal immune responses.

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • The mucosal immune system defends against pathogens at body surfaces.
  • It requires specific responses to pathogens but tolerance to food/environmental antigens.
  • Tight regulation is crucial for mucosal immune system function.

Purpose of the Study:

  • To explore the function and regulation of the mucosal immune system.
  • To investigate the use of pathogenic bacteria and toxins as tools to study mucosal immunity.
  • To understand immune dysfunction resulting from mucosal colonization.

Main Methods:

  • Utilizing bacterial enterotoxins, such as cholera toxin, as mucosal immunogens and adjuvants.
  • Employing infection models with microorganisms like Citrobacter rodentium.

Related Experiment Videos

  • Analyzing host immune responses to specific pathogenic agents and their products.

    • Main Results:

    • Bacterial enterotoxins potently activate both mucosal and systemic immune responses.
    • Pathogenic bacteria serve as effective probes for assessing mucosal immune activity.
    • Microbial colonization can lead to mucosal immune dysfunction.

    Conclusions:

    • The mucosal immune system balances protective immunity with tolerance.
    • Bacterial pathogens and toxins are valuable tools for dissecting mucosal immune mechanisms.
    • Understanding mucosal immunity is vital for addressing infections and immune-related disorders.