Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antioxidant supplementation and pulmonary function at rest and exercise.

C M Deaton1, D J Marlin, C A Roberts

  • 1Centre for Equine Studies, Animal Health Trust, Kentford, Suffolk, UK.

Equine Veterinary Journal. Supplement
|October 31, 2002
PubMed
Summary

Antioxidant supplements did not improve exercise performance or reduce oxidative stress in healthy horses. Additional antioxidant supplementation is likely beneficial only when diets are deficient or exercise is more intense.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydration, mood, and cognition in primary school aged children in the United Kingdom.

Physiology & behavior·2025
Same author

Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response.

Particle and fibre toxicology·2023
Same author

Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England.

PloS one·2023
Same author

Evaluating phytochemical and microbial contributions to atrazine degradation.

Journal of environmental management·2022
Same author

Characterization of the public transit air microbiome and resistome reveals geographical specificity.

Microbiome·2021
Same author

Oxidative stress in air pollution research.

Free radical biology & medicine·2020

Area of Science:

  • Equine Exercise Physiology
  • Nutritional Biochemistry
  • Respiratory Medicine

Background:

  • Oxidative stress is a concern during exercise, potentially impacting performance.
  • Antioxidants are believed to mitigate exercise-induced oxidative stress.
  • Supplementation strategies aim to enhance antioxidant capacity in horses.

Purpose of the Study:

  • To investigate the effects of a 4-week antioxidant supplement on systemic and pulmonary antioxidant capacity in horses.
  • To assess the impact of supplementation on markers of oxidative damage and pulmonary function during exercise.
  • To determine if antioxidant supplementation influences exercise-induced oxidative stress in healthy horses.

Main Methods:

  • Six healthy horses received a 4-week antioxidant supplement or placebo.

Related Experiment Videos

  • Plasma and bronchoalveolar lavage fluid (BALF) were analyzed for antioxidant concentrations (ascorbic acid, alpha-tocopherol) and oxidative stress markers (malondialdehyde, glutathione redox ratio, ascorbic acid redox ratio).
  • Horses underwent an intermittent exercise test to assess pulmonary function and oxidative stress response.

    • Main Results:

    • Supplementation significantly increased plasma ascorbic acid and alpha-tocopherol levels.
    • Pulmonary epithelial lining fluid (ELF) ascorbic acid increased, but not significantly.
    • No significant reduction in oxidative stress markers or improvement in pulmonary function was observed during exercise with supplementation.
    • A strong correlation was found between glutathione redox ratio (GRR) and ascorbic acid redox ratio (ARR) in ELF.

    Conclusions:

    • In healthy horses with adequate dietary antioxidant intake, additional supplementation showed no significant benefit for pulmonary function or oxidative stress during moderate exercise.
    • The benefits of antioxidant supplementation may be more apparent in horses with deficient diets, higher exercise intensities, or underlying health issues.
    • Further research is needed to explore the role of antioxidants under different physiological conditions and exercise demands.