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Immunohistochemical localization of cyclooxygenase-2 in radicular cysts
C-H Tsai1, F-M Huang, L-C Yang
1Department of Oral Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Aim:
The purpose of this study was to investigate the expression of cyclooxygenase-2 (COX-2) in radicular cysts.
Methodology:
Thirty biopsy specimens of radicular cysts were examined using immunohistochemistry. A peroxidase-labelled streptavidin-biotin technique was used for identification of the COX-2. Fisher's exact test (two-tail) was used for statistical analysis of the results.
Results:
The result demonstrated that COX-2 expression was significantly higher in radicular cysts with higher levels of inflammatory infiltrates. COX-2 stain was detected in the lining epithelium, subepithelial fibroblasts, macrophages and endothelial cells in all specimens.
Conclusions:
COX-2 expression is significantly higher in radicular cysts. COX-2 may play an important role in the pathogenesis of radicular cysts.