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Updated: Sep 28, 2026

Differential Scanning Calorimetry — A Method for Assessing the Thermal Stability and Conformation of Protein Antigen
Published on: March 4, 2017
Study of the thermal behavior of azidohetarenes with differential scanning calorimetry
Wolfgang Stadlbauer1, Gerhard Hojas
1Organic Synthesis Group, Department of Chemistry, Karl-Franzens-University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria. wolfgang.stadlbauer@uni-graz.at
Abstract:
Thermal properties of azidohetarenes without reactive ortho-substituents, obtained by DSC analysis, were compared with the DSC data of ortho-phenyl and ortho-acyl substituted azidohetarenes, which give ring closure reactions either to indoles or to five-membered heterocycles such as isoxazoles. The reaction temperatures and reaction enthalpies give both information to prepare the reaction conditions and important safety information and were, in addition, used to find out relations between the temperatures or enthalpies with the three different reaction mechanisms.
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