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Tritium labelling and characterization of the cognition enhancing drug tacrine using several precursors
Judith A Egan1, Richard P Nugent, Crist N Filer
1PerkinElmer Life Sciences, Inc, 549 Albany St, Boston, MA 02118, USA.
Abstract:
Tacrine and its analogues have shown promise as cognition enhancers and potential chemotherapeutic agents for Alzheimer's disease. [3H]tacrine was required to explore its mechanism of action via receptor binding assay and the radioligand was prepared by means of catalytic dehalogenation of several brominated precursors.