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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
Published on: September 21, 2021
Efficient routine production of the 18F-labelled amino acid O-2-18F fluoroethyl-L-tyrosine
1Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425, Jülich, Germany. k.hamacher@fz-juelich.de
Abstract:
A convenient remotely controlled no-carrier-added synthesis of enantiomerically pure O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is described. This allows the distribution of the radiotracer to other laboratories according to the satellite concept. The radiochemical yield obtained within 80 min is about 60%. The FET containing HPLC fraction can be used immediately (after adding sodium chloride) for human application.
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