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Updated: Jul 26, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Pharmacogenomics of organic anion-transporting polypeptides (OATP)
Rommel G Tirona1, Richard B Kim
1Division of Clinical Pharmacology, Department of Medicine, 572 RRB-1, 23rd Ave @ Pierce Ave, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.
Abstract:
The organic anion-transporting polypeptides (OATP) represent a family of proteins responsible for the membrane transport of a large number of endogenous and xenobiotic compounds with diverse chemical characteristics. OATPs are expressed in liver, kidney, brain and intestine suggesting that they may play a critical role in drug disposition. Naturally occurring polymorphisms in OATPs are currently being identified and for some, in vitro transport activities have been characterized. In this article, we review the molecular, biochemical and pharmacological aspects of known human OATPs including the presence and functional relevance of genetic polymorphisms.
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