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An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Resistance to antiretroviral agents in individuals with HIV-1 non-B subtypes
Africa Holguín1, Vincent Soriano
1Service of Infectious Diseases, Instituto de Salud Carlos III, Madrid, Spain.
Abstract:
Naturally occurring polymorphisms at positions involved in resistance to antiretroviral agents are frequently seen in HIV-1 non-B subtypes. Although they do not seem to affect significantly the susceptibility to antiretroviral drugs in vitro, they may facilitate the selection of different pathways and/or a more rapid emergence of drug resistance and treatment failure under not fully suppressive treatment regimens.
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