[The role of moistening on the extrusion and spheronization process]

The pellet is an important oral dosage form, interesting because of its numerous technological and pharmacotherapeutic advantages. Extrusion/spheronization is one of the most frequently employed technologies of pellet manufacture. Similarly as other technologies, also this process of manufacture influences a number of manufacturing and formulating parameters, which are then reflected in the final properties of produced pellets. The present experimental paper is concerned with the role of the moistening agent in the process of extrusion/spheronization and the examination of its effect on the size, density, shape, and mechanical and flow properties of pellets.