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Related Experiment Videos

Interactions between novel micro-organisms and intestinal flora.

P Aureli1, G Franciosa

  • 1Food Department, Food Microbiology Laboratory, Istituto Superiore della Sanità, Rome, Italy. p.aureli@iss.it

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|November 1, 2002
PubMed
Summary

Novel probiotics offer exciting benefits but require rigorous safety evaluations. New microbial strains, including genetically modified ones, must be assessed for potential health risks, especially impacts on gut microbiota.

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Area of Science:

  • Food science and technology
  • Microbiology
  • Biotechnology

Background:

  • Traditionally used microbial strains for food fermentation are Generally Recognized As Safe (GRAS).
  • Many GRAS microbes possess probiotic functionalities, enhancing health benefits.
  • Ongoing discovery and engineering of novel microbial strains with improved technological and functional properties.

Purpose of the Study:

  • To highlight the safety considerations for novel microbial strains, particularly those used as probiotics.
  • To emphasize the need for thorough risk assessment of new and genetically modified microorganisms.
  • To ensure the safety of novel probiotics for human consumption and their impact on gut health.

Main Methods:

  • Review of safety assessment principles for novel microorganisms.

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  • Focus on evaluating direct and indirect harmful effects on host intestinal microflora.
  • Assessment of genetically modified microorganisms for DNA stability and product equivalence.

    • Main Results:

    • Novel microbial strains, while promising, do not automatically share the safety profile of traditional strains.
    • Potential risks to host gut microbiota necessitate careful evaluation.
    • Genetically modified strains require comprehensive characterization to establish substantial equivalence.

    Conclusions:

    • Rigorous safety evaluation is crucial for novel and genetically modified microbial strains intended for food and probiotic use.
    • Assessing impact on gut microbiota is paramount for novel probiotics.
    • Establishing substantial equivalence is key for the regulatory approval of genetically modified microorganisms.