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Probiotics and Helicobacter pylori eradication.
F Canducci1, F Cremonini, A Armuzzi
1Internal Medicine Department, Catholic University, Rome, Italy.
Summary
Lactobacillus species show promise as an alternative or complementary treatment for Helicobacter pylori eradication. Clinical trials indicate their effectiveness in reducing H. pylori levels, potentially offering a new strategy beyond traditional antibiotics.
Area of Science:
- Microbiology
- Gastroenterology
- Probiotics
Background:
- Antibiotic resistance necessitates novel strategies for Helicobacter pylori eradication.
- Lactobacilli exhibit pre-clinical anti-Helicobacter pylori activity.
- Specific strains like Lactobacillus acidophilus and Lactobacillus casei subspecies rhamnosus show inhibitory effects.
Purpose of the Study:
- To investigate the efficacy of Lactobacillus species as an alternative or complementary therapy for Helicobacter pylori eradication.
- To evaluate the potential of Lactobacillus acidophilus strains in H. pylori treatment.
Main Methods:
- Review of pre-clinical studies on Lactobacilli and H. pylori inhibition.
- Analysis of clinical trials assessing Lactobacillus acidophilus (La1) and other strains.
- Evaluation of 13C urea breath test results and eradication rates.
Main Results:
- Lactobacillus species, particularly Lactobacillus acidophilus, demonstrate inhibition of H. pylori growth.
- Clinical studies show persistent reduction in H. pylori levels with Lactobacillus acidophilus La1.
- Eradication was achieved in some patients with Lactobacillus acidophilus alone and when supplemented to standard triple therapy.
Conclusions:
- Lactobacillus species represent a potential complementary or alternative approach to antibiotic therapy for H. pylori eradication.
- Further clinical investigation into probiotic-based strategies for H. pylori infection is warranted.