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17-Ketosteroids in leprosy.

U D Hardas, R G Saoji

    International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
    |July 1, 1975
    PubMed
    Summary
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    Leprosy patients with liver damage showed lower urinary 17-ketosteroid levels, particularly in males. This suggests a link between liver health and steroid excretion in lepromatous leprosy.

    Area of Science:

    • Endocrinology
    • Hepatology
    • Infectious Diseases

    Background:

    • Leprosy, particularly lepromatous leprosy, can affect various organ systems.
    • Liver involvement is a known complication in leprosy patients.
    • Urinary 17-ketosteroids are metabolites of androgens and can reflect endocrine and metabolic status.

    Purpose of the Study:

    • To investigate the relationship between urinary 17-ketosteroid levels and liver function in lepromatous leprosy.
    • To explore the correlation between histopathologic findings, serum G.G.P.T. values, and urinary 17-ketosteroids.

    Main Methods:

    • Estimation of urinary 17-ketosteroids in 29 lepromatous leprosy patients.
    • Analysis of histopathologic findings.
    • Measurement of serum G.G.P.T. (Glutamic-pyruvic transaminase) values.

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    Main Results:

    • Lower urinary 17-ketosteroid values were observed in cases with definite leproma affecting the liver.
    • A correlation was found between decreased 17-ketosteroid levels and indicators of liver damage.
    • This association was more pronounced in male patients compared to females.

    Conclusions:

    • Liver damage in lepromatous leprosy is associated with reduced urinary 17-ketosteroid excretion.
    • Urinary 17-ketosteroid levels may serve as an indicator of liver involvement in leprosy.
    • Gender influences the relationship between liver damage and steroid metabolism in leprosy.