Related Experiment Video

Updated: Aug 18, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

Pericardial Diseases

Samer S. Kabbani1, Martin M. LeWinter

  • 1University of Vermont/Fletcher Allen Health Care, 111 Colchester Avenue, McClure 1/Cardiology, Burlington, VT 05401, USA. Samer.kabbani@vtmednet.org

Current Treatment Options in Cardiovascular Medicine
|November 1, 2002
PubMed

Insights

Prompt treatment of pericardial diseases, including acute idiopathic pericarditis with indomethacin and recurrent pericarditis with colchicine, improves outcomes. Surgical pericardiectomy is key for constrictive pericarditis, while pericardiocentesis treats cardiac tamponade.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Pericardial diseases present with diverse acute and chronic complications.
  • Early diagnosis and prompt intervention are crucial for resolving hemodynamic issues.

Purpose of the Study:

  • To outline diagnostic and treatment strategies for various pericardial diseases.
  • To emphasize timely management for optimal patient outcomes.

Main Methods:

  • Treatment of acute idiopathic pericarditis focuses on symptom relief with nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Management of chronic recurrent idiopathic pericarditis involves colchicine.
  • Surgical pericardiectomy is indicated for constrictive pericarditis before myocardial fibrosis.
  • Cardiac tamponade is managed with volume expansion and pericardiocentesis.

Main Results:

  • NSAIDs effectively resolve acute idiopathic pericarditis symptoms within 24-48 hours.
  • Colchicine is recommended for chronic recurrent idiopathic pericarditis.
  • Early pericardiectomy offers definitive treatment for constrictive pericarditis.
  • Pericardiocentesis is the primary intervention for cardiac tamponade.

Conclusions:

  • Tailored treatment strategies for pericardial diseases significantly improve patient prognosis.
  • Prompt management of cardiac tamponade and constrictive pericarditis is essential.
  • Monitoring asymptomatic pericardial effusions with echocardiography guides intervention decisions.

More Related Videos

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

An Intact Pericardium Ischemic Rodent Model07:15

An Intact Pericardium Ischemic Rodent Model

Published on: September 2, 2021

Related Concept Videos

Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...