Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative determination of polymorphic composition in intact compacts by parallel-beam X-ray powder

Wenjin Cao1, Simon Bates, Garnet E Peck

  • 1Department of Industrial and Physical Pharmacy, School of Pharmacy, 1336 Robert E. Heine Pharmacy Building, Purdue University, 47907-1336, West Lafayette, IN, USA.

Journal of Pharmaceutical and Biomedical Analysis
|November 1, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formation of Unusual Deprotomers of Citric Acid and Sodium Citrate Aggregates: A Photoelectron Spectroscopy and Computational Study.

The journal of physical chemistry letters·2026
Same author

Unwrapping the Dodecaborane Core: Structure, Electronic Properties, and Chemical Reactivity Across the Complete [B<sub>12</sub>I<sub><i>n</i></sub>]<sup>-</sup> Series (<i>n</i> = 11-1).

Journal of the American Chemical Society·2026
Same author

Electronic Structures and Stabilities of Trimethylsilyl-Masked Pnictogen and Chalcogen Complex Anions and Comparisons to Their Hydrides: A Combined Photoelectron Spectroscopy and Computational Study.

Inorganic chemistry·2026
Same author

Gas-phase negative ion photoelectron spectroscopy and reactivity of phenylacetylide PhCC.

Physical chemistry chemical physics : PCCP·2025
Same author

The Deprotonation Sites of Gas Phase Uridine and Pseudouridine: Implications for mRNA Vaccines.

The journal of physical chemistry letters·2025
Same author

Identification and Molecular Characterization of Two Novel Picorna-Like Viruses in <i>Armigeres subalbatus</i> Mosquitoes in Yunnan, China.

Vector borne and zoonotic diseases (Larchmont, N.Y.)·2025

This study introduces a new method using parallel-beam X-ray powder diffractometry to quantify crystal forms in intact compacts. This non-invasive technique accurately determines polymorphic composition without sample preparation.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Analytical Chemistry

Background:

  • Polymorphism significantly impacts drug properties and efficacy.
  • Accurate quantification of polymorphs in solid dosage forms is crucial for quality control.
  • Existing methods for polymorph analysis often require sample destruction or extensive preparation.

Purpose of the Study:

  • To develop and validate a novel, non-invasive method for determining polymorphic composition in intact pharmaceutical compacts.
  • To utilize parallel-beam X-ray powder diffractometry for quantitative analysis of co-existing polymorphs.
  • To establish a straightforward and reliable technique for polymorph quantitation in solid-state drug forms.

Main Methods:

  • Development of a parallel-beam X-ray powder diffractometry (PXRD) method.

Related Experiment Videos

  • Analysis of intact compacts of chlorpropamide and glycine polymorphic systems.
  • Quantification using the integrated intensity ratio of selected peaks and profile fitting.
  • Utilizing Shimadzu XRD-6000 software for data processing.

    • Main Results:

    • Excellent linear correlation was achieved for quantifying polymorphs in both chlorpropamide and glycine systems.
    • The method proved insensitive to the convex surface shape of the compacts.
    • This represents the first reported non-invasive X-ray diffraction quantitation of crystal forms in intact compacts.

    Conclusions:

    • Parallel-beam X-ray powder diffractometry offers a simple and effective non-invasive method for polymorph quantitation in intact compacts.
    • The technique eliminates the need for sample grinding or destruction, preserving sample integrity.
    • Further research is underway to apply this method to formulated tablets.