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Limbic cortical injury sustained during adulthood leads to schizophrenia-like syndrome
George E Jaskiw1, John F Kenny
1Louis Stokes Cleveland VAMC General Mental Health Care Line and Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44144, USA. gxj5@po.cwru.edu
Schizophrenia Research
|November 1, 2002
Abstract:
Within 1 year of severe trauma to the left anterior temporal lobe and minor injury to the frontal lobes, a 35-year-old individual developed classic positive and negative symptoms of schizophrenia. His antipsychotic drug-induced parkinsonism was greater on the left side, suggesting increased left striatal dopaminergic transmission. The authors propose that even in adulthood, significant and selective disruption of fronto-temporal connectivity is sufficient to produce a phenocopy of schizophrenia.