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Related Experiment Videos

Cardioprotection with grapes.

Jianhua Cui1, Bela Juhasz, Arpad Tosaki

  • 1Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

Journal of Cardiovascular Pharmacology
|November 1, 2002
PubMed
Summary

Standardized grape extract (SGE) shows cardioprotective effects in rats, reducing heart damage from ischemia and reperfusion. Grapes may offer benefits similar to wine for heart health.

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Area of Science:

  • Cardiovascular Science
  • Nutritional Science
  • Pharmacology

Background:

  • Wine consumption is linked to reduced coronary heart disease.
  • Grapes are the source of wine, prompting investigation into their independent cardioprotective potential.

Purpose of the Study:

  • To evaluate the cardioprotective effects of standardized grape extract (SGE) in a rat model.
  • To determine if SGE can mitigate myocardial ischemia-reperfusion injury.

Main Methods:

  • Male Sprague-Dawley rats were administered SGE (50, 100, or 200 mg/kg/day) or control (glucose/fructose) for 3 weeks.
  • Hearts underwent 30 minutes of ischemia followed by 2 hours of reperfusion.
  • Cardiac function and myocardial infarction size were assessed; oxidative stress markers were measured.

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Main Results:

  • SGE at 100 and 200 mg/kg/day significantly improved post-ischemic cardiac function and reduced myocardial infarction.
  • SGE decreased heart malonaldehyde content, indicating reduced oxidative stress.
  • In vitro tests confirmed SGE's ability to scavenge superoxide and hydroxyl radicals.

Conclusions:

  • Standardized grape extract confers resistance to myocardial ischemia-reperfusion injury in rats.
  • Grapes possess cardioprotective properties, potentially contributing to the benefits associated with moderate wine consumption.
  • SGE's antioxidant activity plays a role in its protective effects against oxidative stress during ischemia-reperfusion.