Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphological studies in tissues surrounding alloarthroplastic joints.

K Heilmann, P B Diezel, J A Rossner

    Virchows Archiv. A, Pathological Anatomy and Histology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis.

    Mucosal immunology·2017
    Same author

    Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with prognostic relevance for human breast cancer.

    Oncogene·2017
    Same author

    The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 ameliorates acute DSS colitis.

    European journal of microbiology & immunology·2014
    Same author

    IgA antibody production by intrarectal immunization of mice using recombinant major capsid protein of hamster polyomavirus.

    European journal of microbiology & immunology·2014
    Same author

    CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria.

    Cell death and differentiation·2007
    Same author

    The influence of the chemical composition of cell culture material on the growth and antibody production of hybridoma cells.

    Journal of biotechnology·2005
    Same journal

    Primary carcinoid tumor of the ear.

    Virchows Archiv. A, Pathological anatomy and histology·1982
    Same journal

    Epithelial dysplasias in chronic pancreatitis.

    Virchows Archiv. A, Pathological anatomy and histology·1982
    Same journal

    Pathology of chronic vitamin E deficiency in fatal familial intrahepatic cholestasis (Byler disease).

    Virchows Archiv. A, Pathological anatomy and histology·1982
    Same journal

    An ultrastructural and morphometric study of bladder tumours (II).

    Virchows Archiv. A, Pathological anatomy and histology·1982
    Same journal

    Striae: morphological aspects of connective tissue.

    Virchows Archiv. A, Pathological anatomy and histology·1982
    Same journal

    Peanut lectin: a useful tool for detecting Hodgkin cells in paraffin sections.

    Virchows Archiv. A, Pathological anatomy and histology·1982
    See all related articles

    Tissue reactions to artificial joint materials cause loosening. Abraded particles from joint prostheses trigger inflammation, leading to bone degradation and implant failure. This foreign body response is a primary cause of artificial joint loosening.

    Area of Science:

    • Orthopedic Surgery
    • Biomaterials Science
    • Histopathology

    Background:

    • Revision surgeries for hip and knee arthroplasty are often necessitated by prosthetic loosening.
    • Understanding the biological response to implant materials is crucial for improving arthroplasty longevity.

    Purpose of the Study:

    • To investigate the morphological and ultrastructural changes in soft tissues surrounding failed alloplastic joints.
    • To elucidate the role of abraded biomaterial particles in prosthetic loosening.

    Main Methods:

    • Histological, histochemical, and ultrastructural analysis of periprosthetic soft tissues from explanted hip and knee arthroplasties.
    • Correlation of morphological findings with implant material type and time in situ.

    Main Results:

    Related Experiment Videos

    • Foreign body giant cells phagocytose acrylic cement particles.
    • Abraded polyester and polyethylene particles induce granulomatous inflammation and histiocytic proliferation.
    • These reactions lead to fibrous membrane thickening and bone resorption, impairing implant anchorage.

    Conclusions:

    • Foreign body reactions to abraded alloplastic particles are a significant factor in prosthetic loosening.
    • Polyester components may elicit a more pronounced early reaction compared to polyethylene.
    • Minimizing particle generation is key to enhancing arthroplasty survival.