Related Experiment Video
Updated: Aug 19, 2026
Assessing the Secretory Capacity of Pancreatic Acinar Cells
Published on: August 28, 2014
Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging
Jingshan Gong1, Jianmin Xu, Kangrong Zhou
1Department of Radiology, Shenzhen People's Hospital, China. jshgong@sina.com.cn
Objective:
To investigate role of exocrine cells in the pancreatic enhancement images at Manganese (II) N, N'-dipyridoxylethlenediamine-N, N'-diacetate 5, 5'-bisc (Mn-DPDP)-enhanced magnetic resonance (MR) imaging.
Methods:
Artificial pancreatic leakage was constructed in six dogs using a fistula tube inserted into the duodenum papillae. Pancreatic juice was collected before and after intravenous infusion of 2 ml/kg of Mn-DPDP at a rate of 2 - 3 ml/min. The Mn content of pancreatic juice was measured by atomic absorption spectroscopy. T(1)-weighted spin-echo images and T(1)-weighted spoiled phase gradient-echo (SPGR) images were obtained prior and approximately 30 min after the administration of Mn-DPDP at 1.5T.
Results:
The Mn content of pancreatic secretion increased 60.47 +/- 21.83 micro g/dl after the administration of Mn-DPDP (t = 6.785, P < 0.01). The signal/noise ratio (S/N) of the pancreas increased 53 percent +/- 49 percent and 62 percent +/- 44% on T(1)W spin echo images and SPGR images, respectively.
Conclusions:
Exocrine cells of the pancreas can absorb manganese and excrete it through the pancreatic juice. Exocrine cells play an important role in the enhancement of the pancreas in MR imaging with Mn-DPDP.
Insights
Pancreatic exocrine cells absorb and excrete manganese (Mn-DPDP), significantly enhancing pancreatic visibility in magnetic resonance (MR) imaging. This study clarifies the role of these cells in Mn-DPDP-enhanced MR imaging of the pancreas.
Area of Science:
- Medical Imaging
- Gastroenterology
- Biochemistry
Background:
- Magnetic resonance (MR) imaging is crucial for visualizing pancreatic structures.
- Contrast agents like Manganese (II) N, N'-dipyridoxylethlenediamine-N, N'-diacetate 5, 5'-bisc (Mn-DPDP) enhance MR imaging.
- The specific role of pancreatic exocrine cells in Mn-DPDP enhancement was not fully understood.
Purpose of the Study:
- To investigate the role of pancreatic exocrine cells in Mn-DPDP-enhanced MR imaging.
- To determine if exocrine cells absorb and excrete Mn-DPDP.
- To assess the impact of Mn-DPDP on pancreatic enhancement in MR images.
Main Methods:
- Artificial pancreatic leakage was created in six dogs.
- Pancreatic juice was collected before and after Mn-DPDP infusion.
- Manganese content in pancreatic juice was measured using atomic absorption spectroscopy.
- T(1)-weighted spin-echo and SPGR MR images were acquired before and after Mn-DPDP administration.
Main Results:
- Manganese content in pancreatic secretion significantly increased post-Mn-DPDP administration (P < 0.01).
- Pancreatic signal-to-noise ratio (S/N) increased by 53% on T(1)W spin echo images.
- Pancreatic S/N increased by 62% on SPGR images.
Conclusions:
- Pancreatic exocrine cells absorb manganese (Mn-DPDP).
- Manganese is excreted via pancreatic juice.
- Exocrine cells play a significant role in pancreatic enhancement during Mn-DPDP-enhanced MR imaging.
More Related Videos
06:24Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
07:44Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
Published on: August 7, 2015