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Significance and expression of vascular endothelial growth factor and E-cadherin in non-small cell lung Carcinomas
Tonghua Mei1, Liping Zhang, Ying Ma
1Department of Lung, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China.
Objectives:
To study the expression of vascular endothelial growth factor (VEGF) and E-cadherin (E-cd) in non-small cell lung carcinomas (NSCLC) and explore the mechanism of invasion and metastasis of tumor cell.
Method:
The expression of VEGF and E-cd was analyzed in surgical specimens (43 cases of NSCLC) by SP immunohistochemical method.
Results:
The positive rates of VEGF in the case of good-differentiation and poor-middle-differentiation were 60.0% and 86.9% respectively, and those of E-cd were 65.0% and 34.9%. The expression of VEGF and E-cd in the case of metastasis was significantly different from that in the case without metastasis.
Conclusion:
The expression of VEGF and E-cd is correlated well with invasion and metastasis of NSCLC.