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Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat
1Center of Cleft Palate, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Objective:
To evaluate whether or not administration of vitamin B(6) (vitB(6)) has preventive effects on cleft palate formation.
Methods:
On the 14, 15 day of gestation, the pregnant rats were treated with administration of vitB(6) (10 mg/kg weight im) before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only.
Results:
Treatment with administration of vitB(6) before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32.35%) was significantly less than that given DEX only (64.52%). The proportion of the palatal cleft type was also changed significantly.
Conclusions:
VitB(6) decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB(6) may have preventive effects on cleft palate formation.
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