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Related Concept Videos

Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Pinocytosis00:43

Pinocytosis

Cells use energy-requiring bulk transport mechanisms to transfer large particles, or large amounts of small particles, into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
Phagocytosis00:41

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). It is perhaps unsurprising, that many...
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
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Pinocytosis00:38

Pinocytosis

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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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Related Experiment Video

Updated: Jul 19, 2026

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets
07:59

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Published on: October 15, 2021

Colloidosomes: selectively permeable capsules composed of colloidal particles.

A D Dinsmore1, Ming F Hsu, M G Nikolaides

  • 1Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA. dinsmore@physics.umass.edu

Science (New York, N.Y.)
|November 2, 2002
PubMed
Summary

Researchers developed a method to create hollow, elastic capsules called colloidosomes. These versatile structures offer precise control over size, permeability, and strength, with potential applications in cellular immunoisolation.

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Area of Science:

  • Materials Science and Engineering
  • Colloid and Interface Science
  • Biomaterials Engineering

Background:

  • Fabricating microcapsules with tunable properties remains a significant challenge in materials science.
  • Existing methods often lack precise control over shell characteristics like permeability and mechanical strength.
  • The need for robust, controllable encapsulation systems is critical for applications ranging from drug delivery to cellular encapsulation.

Purpose of the Study:

  • To develop a novel fabrication method for creating solid capsules with precisely controlled properties.
  • To investigate the self-assembly of colloidal particles for shell formation.
  • To demonstrate the versatility and potential applications of the fabricated structures, termed colloidosomes.

Main Methods:

  • Utilized the self-assembly of colloidal particles at the interface of emulsion droplets.
  • Locked assembled particles to form elastic shells around the emulsion core.
  • Transferred the resultant colloidosomes to a matching continuous-phase fluid to ensure structural integrity.

Main Results:

  • Successfully fabricated hollow, elastic shells (colloidosomes) with precise control over size, permeability, and mechanical strength.
  • Demonstrated the generality of the method using various solvents, colloidal particles, and encapsulated contents.
  • Showcased the robustness of the colloidosomes and their potential for cellular immunoisolation.

Conclusions:

  • The self-assembly approach provides a versatile and robust platform for fabricating engineered microcapsules (colloidosomes).
  • Colloidosomes offer tunable properties, enabling tailored applications in various scientific and technological fields.
  • The demonstrated potential for cellular immunoisolation highlights the significance of this fabrication technique for biomedical applications.