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Updated: Aug 12, 2026
08:40
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Urinary tract infection and other pediatric considerations
1Department of Nuclear Medicine, The Prince of Wales and Sydney Children's Hospital, University of New South Wales, Randwick NSW, Sydney, Australia.
The Quarterly Journal of Nuclear Medicine : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR)
|November 2, 2002
Summary
Pediatric urinary tract infections can cause chronic kidney issues, especially with reflux or obstruction. (99m)Tc-DMSA scintigraphy and diuresis renography help evaluate these complications, though methods remain debated.
Area of Science:
- Pediatric Nuclear Medicine
- Pediatric Nephrology
- Diagnostic Imaging
Background:
- Childhood urinary tract infections (UTIs) can lead to chronic kidney sequelae, including renal scarring.
- Vesico-ureteric reflux and urinary tract obstruction are key risk factors for severe complications.
- Accurate evaluation of renal damage and obstruction is crucial for timely intervention.
Purpose of the Study:
- To review the role of (99m)Tc dimercaptosuccinic acid ((99m)Tc-DMSA) scintigraphy in evaluating renal complications of childhood UTIs.
- To discuss the diagnostic utility and controversies surrounding diuresis renography in pediatric renal obstruction.
- To highlight the challenges in managing neonatal hydronephrosis.
Main Methods:
- Utilizes (99m)Tc-DMSA scintigraphy for assessing acute pyelonephritis and chronic renal cortical scarring.
- Employs diuresis renography as a tool for diagnosing and grading urinary tract obstruction in children.
- Reviews established and controversial methodologies in pediatric nuclear medicine imaging.
Main Results:
- (99m)Tc-DMSA scintigraphy is highly accurate for detecting renal scarring and complications.
- Diuresis renography is valuable for obstruction assessment, but lacks a standardized protocol.
- Diagnosis and management of pediatric renal obstruction and neonatal hydronephrosis present significant challenges.
Conclusions:
- Effective management of childhood UTIs requires accurate imaging to prevent long-term renal damage.
- Standardization of diuresis renography techniques is needed to improve diagnostic consistency in pediatric nuclear medicine.
- Controversies in surgical management of neonatal hydronephrosis underscore the need for further research and consensus.
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