Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tooth development is independent of a Hox patterning programme.

Chela T James1, Atsushi Ohazama, Abigail S Tucker

  • 1Department of Craniofacial Development, GKT Dental Institute, Kings College London, Guy's Hospital, London Bridge, London, United Kingdom.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|November 2, 2002
PubMed
Summary

Hox genes pattern the skull but do not control tooth development. Tooth formation in the first branchial arch arises from local interactions, independent of Hox gene expression patterns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel CHD7 Variants Associated with an Expanded Orofacial and Dental Phenotype.

European journal of dentistry·2026
Same author

Exercise-induced lactic acidemia associated with a SLC16A13 biallelic variant.

NPJ genomic medicine·2026
Same author

FGF signalling orchestrates multiple roles during salivary gland branching morphogenesis.

Developmental biology·2026
Same author

Secondary cartilage in the murine medial pterygoid plate has a critical role in the pathfinding of the tensor veli palatini.

Journal of anatomy·2026
Same author

Bone regeneration of rat calvarial defect using biomimetic keratin-based membranes.

Biomaterials advances·2026
Same author

Analysis of Eya1 and Tbx1 mutants highlights interactions between the muscle and developing cartilage during external ear formation.

Development (Cambridge, England)·2026

Area of Science:

  • Developmental biology
  • Evolutionary developmental biology
  • Genetics

Background:

  • Hox genes are crucial for embryonic patterning and positional information.
  • Hox gene expression in the first branchial arch is linked to jaw evolution.
  • Teeth develop in the first branchial arch, suggesting potential Hox gene regulation.

Purpose of the Study:

  • To investigate the role of Hox genes, specifically Hoxa2, in mammalian tooth development.
  • To determine if tooth formation is regulated by the same axial patterning mechanisms as cranial skeletal elements.

Main Methods:

  • Analysis of Hoxa2 gene expression during tooth development.
  • Experimental manipulation of Hoxa2 expression in the first branchial arch.
  • Chimeric recombination experiments involving first and second branchial arch tissues.

Related Experiment Videos

Main Results:

  • Overexpression of Hoxa2 did not affect tooth development in the first branchial arch.
  • Tooth development occurred in a Hoxa2-positive environment when second arch mesenchyme was combined with first arch epithelium.
  • Unlike cartilage and bone, tooth development was not influenced by Hoxa2 alterations.

Conclusions:

  • Tooth development in the first branchial arch is regulated by local interactions, not by the Hox gene axial patterning program.
  • The evolutionary development of teeth in the first branchial arch is independent of the Hox gene loss associated with jaw development.