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[Hodgkin's disease presenting with progressive liver failure].
Masaharu Nohgawa1, Noboru Yonetani, Tateo Sugiyama
1Second Department of Intern Medicine, Japan Red Cross Society, Wakayama Medical Center.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|November 5, 2002
Summary
This case study details a 70-year-old man with Hodgkin's disease presenting with fever and liver dysfunction. The unusual presentation suggests the liver may have been the primary site of the disease.
Area of Science:
- Oncology
- Hepatology
- Hematology
Background:
- Hodgkin's disease typically presents with lymphadenopathy.
- Liver dysfunction and fever are less common initial symptoms.
Observation:
- A 70-year-old male with Hodgkin's disease presented with fever, jaundice, and liver enzyme abnormalities.
- Minimal cervical lymphadenopathy was noted; CT scans revealed no other enlarged lymph nodes.
- Bone marrow biopsy showed granulomas, but no tumor cells were detected.
Findings:
- Diagnosis of Hodgkin's disease was confirmed via cervical lymph node biopsy.
- Treatment with chemotherapy led to rapid improvement in jaundice and fever.
- Liver dysfunction preceded cytopenia, and lymphadenopathy resolved post-treatment.
Implications:
- This case highlights an atypical presentation of Hodgkin's disease.
- The findings suggest the liver may serve as an unusual primary site for Hodgkin's disease.
- Early diagnosis and treatment are crucial for managing atypical presentations.