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[Intracranial Hodgkin disease: case report]
1Service de radiothérapie, Institut national d'oncologie Sidi Mohamed Ben Abdellah, BP 6213 RI, Rabat, Maroc. Halm.benomar73@caramail.com
Summary
Intracranial relapse of Hodgkin disease is rare. This case study details a patient with an unusual brain relapse 24 months post-treatment, successfully managed with radiation and chemotherapy.
Area of Science:
- Oncology
- Neurology
- Hematology
Background:
- Hodgkin disease is a lymphoma with varied presentations.
- Intracranial involvement in Hodgkin disease is infrequent, particularly as an isolated relapse.
Observation:
- A 24-year-old male with Stage III B Hodgkin disease experienced an isolated intracranial relapse 24 months after initial multi-drug and radiation therapy.
- The patient received whole brain irradiation (40 Gy/20 fractions).
Findings:
- Six months post-irradiation, the patient had a second relapse involving bilateral inguinal lymph nodes.
- Subsequent treatment with second-line polychemotherapy led to disease remission.
Implications:
- This case highlights the possibility of late, isolated intracranial relapse in Hodgkin disease.
- It underscores the need for vigilance in monitoring for unusual relapse patterns.
- Effective management strategies may involve multimodal therapy including radiation and chemotherapy.