Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The pathophysiology of primary hyperparathyroidism.

Edward M Brown1

  • 1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|November 5, 2002
PubMed
Summary

The parathyroid glands regulate blood calcium levels via the calcium-sensing receptor (CaSR). Defects in CaSR function, due to inherited mutations or reduced expression, lead to hypercalcemia in conditions like primary hyperparathyroidism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interoperability of health data: the importance of including physicians.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2025
Same author

The Calcium-Sensing Receptor and 25-Hydroxyvitamin D-1α-Hydroxylase Interact to Modulate Skeletal Growth and Bone Turnover.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2018
Same author

Calcium-Sensing Receptor Autoantibodies in Patients with Autoimmune Polyendocrine Syndrome Type 1: Epitopes, Specificity, Functional Affinity, IgG Subclass, and Effects on Receptor Activity.

Journal of immunology (Baltimore, Md. : 1950)·2018
Same author

Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium-sensing receptor.

Clinical endocrinology·2018
Same author

Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

François Leuret: the last moral therapist.

History of psychiatry·2017

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Parathyroid glands maintain extracellular calcium (Ca(o)2+) homeostasis.
  • The calcium-sensing receptor (CaSR) on parathyroid chief cells detects Ca(o)2+ levels.
  • Primary hyperparathyroidism (PHPT) involves an elevated Ca(o)2+ set point.

Purpose of the Study:

  • To elucidate the mechanisms underlying altered Ca(o)2+ sensing in hyperparathyroid disorders.
  • To differentiate the roles of CaSR gene mutations versus CaSR expression levels in hypercalcemia.

Main Methods:

  • Analysis of inherited disorders (FHH, NSHPT) caused by CaSR gene mutations.
  • Investigation of CaSR expression in pathological parathyroid tissue from PHPT patients.

Related Experiment Videos

Main Results:

  • Inactivating CaSR mutations cause inherited hypercalcemic conditions (FHH, NSHPT) due to Ca(o)2+ resistance.
  • PHPT is characterized by reduced expression of functional CaSRs in parathyroid glands, not CaSR gene mutations.
  • Both inherited generalized and acquired tissue-specific Ca(o)2+ resistance contribute to PTH-dependent hypercalcemia.

Conclusions:

  • Altered CaSR function, either through inherited mutations or reduced expression, is central to PTH-dependent hypercalcemia.
  • PHPT involves acquired resistance to Ca(o)2+ in parathyroid glands due to decreased CaSR expression.
  • Understanding CaSR mechanisms is crucial for managing hypercalcemic disorders.